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KMID : 0613820140240070762
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Journal of Life Science
2014 Volume.24 No. 7 p.762 ~ p.768
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Expressional Analysis of Two Genes (Scd1 and Idi1) Down-regulated by Starvation Stress
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Cho Jun-Ho
Kwon Young-Sook
Kim Dong-Il
Kim Bok-Jo
Kwon Ki-Sang
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Abstract
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Diet exerts a major stress on the body and may affect gene expression and physiological functions. Understanding of cellular responses during starvation is necessary in developing strategies to reduce damage caused by diet. In this study, we isolated 10 genes (Comt, RGN, Scd1, Temt, Idi1, Fabp5, Car3, Cyp2c70, Pinx1, and Poldip3) that are down-regulated in starvation and are closely related to liver metabolism. Water supply during starvation had no effect on the induction of apoptosis, autophagy, and ERQC. The genes down-regulated by starvation were associated with many related pathways rather than limited to the liver homeostasis pathway. Water supply during starvation is important. However, maintaining NaCl homeostasis is more important. The results are thought to be closely related to gender-specific metabolism in starvation and NaCl.
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KEYWORD
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Idi1, Scd1, starvation
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